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C—H to C—O Hydroxylations

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A preparative small-molecule mimic of liver CYP450 enzymes in the aliphatic C–H oxidation of carbocyclic N-heterocycles

Rachel K. Chambers, Jacob D. Weaver, Jinho Kim, Jason L. Hoar, Shane W. Krska, and M. Christina White

 

Check out MCW, Rachel and Jake discussing the paper: “Mn(CF3PDP): CYP450 in a Bottle”. https://www.youtube.com/watch?v=ZrV5IPFJc2o

 

Supplementary Information

Rachel Chambers

Eli Lilly

Jake Weaver

UIUC, White Group

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Late-stage oxidative C(sp3)–H methylation

Kaibo Feng, Raundi Quevedo, Jeffrey Kohrt, Martins S. Oderinde, Usa Reilly and M. Christina White

Supplementary Information
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Kaibo Feng

MIT, Buchwald Group

Raundi Quevedo

UIUC, White Group

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Chemoselective Tertiary C—H Hydroxylation for Late-Stage Functionalization with Mn(PDP)/Chloroacetic Acid Catalysis

Rachel Chambers, Jinpeng Zhao, Connor Delaney, and M.Christina White

Supplementary Information
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Rachel Chambers

UIUC, White Group 

Jinpeng Zhao

Corteva, Agro Sciences

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Chemoselective Methylene Oxidation in Aromatic Molecules
Jinpeng Zhao, Takeshi Nanjo, Emilio C. de Lucca Jr. and M. Christina White

Supplementary Information
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Takeshi Nanjo

Asst. Professor

Kyoto University

Jinpeng Zhao

Agro Sciences

Corteva 

Emilio de Lucca

Asst. Professor

Univ. of Campinas

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Remote, Late-Stage Oxidation of Aliphatic C–H Bonds in Amide-Containing Molecules

Takeshi Nanjo, Emilio C. de Lucca Jr.‡ and M. Christina White

Supplementary Information
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Takeshi Nanjo

Assistant Professor

Kyoto University

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Emilio de Lucca

Assistant Professor

University of Campinas

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Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

Thomas J. Osberger, Donald C. Rogness, Jeffery T. Kohrt, Antonia F. Stepan and M. Christina White

Supplementary Information
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Thomas Osberger

Assistant Professor,

Cal Poly Pomona

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Remote Oxidation of Aliphatic C−H Bonds in Nitrogen-Containing Molecules

Jennifer M. Howell, Kaibo Feng, Joseph R. Clark, Louis J. Trzepkowski, and M. Christina White

Supplementary Information
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Jennifer Howell

Eli-Lilly,

Discovery Chemistry

Joseph Clark

Marquette University

Assistant Professor

Kaibo Feng

MIT,

Buchwald Group

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Catalyst-Controlled Aliphatic C–H Oxidations with a Predictive Model for Site-Selectivity

Paul E. Gormisky and M. Christina White

Supplementary Information
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Paul Gormisky

Odyssey Therapeutics  

Senior Director

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Cafestol to Tricalysiolide B and Oxidized Analogues: Biosynthetic and Derivitization Studies Using Non-heme Iron Catalyst Fe(PDP)

M. A. Bigi, P. Liu, L. Zou, K. N. Houk, and M. C. White

Supplementary Information
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Marinus Bigi

Catalysis Discovery,

Dow Chemical

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Directed Metal (Oxo) Aliphatic C-H Hydroxylations: Overriding Substrate Bias

M. A. Bigi, S. A. Reed, and M. C. White

Supplementary Information
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Marinus Bigi

Catalysis Discovery,

Dow Chemical

Sean Reed

Wilson Sonsini Goodrich & Rosati

Patent Agent

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Diverting non-haem iron catalysed aliphatic C—H hydroxylations towards desaturations

M.A. Bigi, S.A. Reed and M.C. White

Supplementary Information
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Marinus Bigi

Catalysis Discovery,

Dow Chemical

Sean Reed

Wilson Sonsini Goodrich & Rosati

Patent Agent

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Combined Effects on Selectivity in Fe-Catalyzed Methylene Oxidation

M.S. Chen and M.C. White

Supplementary Information
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Mark Chen

Lehigh University

Assistant Professor

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The Fe(PDP)-catalyzed aliphatic C-H oxidation: a slow addition protocol

N.A. Vermeulen; M.S. Chen; and M.C. White

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Nicolaas Vermeulen

Corteva,

Agro Sciences

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Mark Chen

Lehigh University

Assistant Professor

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A Predictably Selective Aliphatic C-H Oxidation Reaction for Complex Molecule Synthesis

M.S. Chen and M.C. White

Supplementary Information
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Mark Chen

Lehigh University

Assistant Professor

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